Programme

Lecturer: Prof. Ruben Abagyan (University of California, USA)
The course site: University campus Bohunice, Kamenice 5, Brno, Czech Republic
Lectures and exercises will take place in computer room 1.18 in A4 building

Monday, 1 November
9:00Course opening (bulding A4, computer room 1.18)
9:00-10:30Lecture
10:30-11:00Coffee break
11:00-12:30Lecture
12:30-14:00Lunch
14:00-15:30Lecture
15:30-16:00Coffee break
16:00-17:30Lecture
Tuesday, 2 November
9:00-10:30Lecture
10:30-11:00Coffee break
11:00-12:30Lecture
12:30-14:00Lunch
14:00-15:30Lecture
15:30-16:00Coffee break
16:00-17:30Lecture
Wednesday, 3 November
9:00-10:30Lecture
10:30-11:00Coffee break
11:00-12:30Lecture
12:30-14:00Lunch
14:00-15:30Lecture
15:30-16:00Coffee break
16:00-17:30Lecture
Thursday, 4 November
9:00-10:30Lecture
10:30-11:00Coffee break
11:00-12:30Lecture
12:30-16:15Lunch and break
16:15-17:15Examination test
 

Abstract

    Biological metabolites, drug substances and bio-macromolecules
    Sizes, moles, temperature and the gas law
    Basic biophysics and diffusion
    Introduction to 3D structure
    Thermodynamics, Heat, Calorimetry
    Chemical potential, Equilibria.
    Henry and Raoult's Laws
    Osmosis and colligative properties.
    Molecular Energetics of Ligand-Receptor Interactions
        Electrostatics
        Van der Waals and hydrophobic Interactions and hydrogen bonding
        Solvation energetics
    Examples:
        BRAF kinase with Sorafenib
        Transthyretin with experimental amyloidogenesis inhibitor
        Vitamin D-binding protein with vitamin D analog
    Acids/Bases. Henderson-Hasselbach equation
    Crystals and Protein Therapeutics
    Experimental Methods for Pharmaceutical Discovery
        X-ray crystallography, NMR, Mass Spectrometry, Chromatography.
    Practical Sessions and Quizzes.