Laboratory of Structural Proteins of Eukaryotic Chromosomes (SPEC)
The SMC (structure maintenance of chromosome) complexes are conserved from bacteria to humans. They are key components of higher-order chromatin structures and play important roles in genome stability. Three SMC complexes are present in most eukaryotic cells: cohesin (SMC1/3), condensin (SMC2/4) and SMC5/6 complex. Cohesin can embrace two sister chromatids and is essential for proper chromosome segregation. Condensin is critical for mitotic chromosome condensation. The SMC5/6 complex is involved in the homologous recombination-based DNA repair, in replication fork stability and processing, and in cohesin regulation.
Figure: Members of the Laboratory of Structural Proteins of Eukaryotic Chromosomes.