Research group Recombination and DNA Repair (LORD)

Head:

Assoc. Prof. Mgr. Lumír Krejčí, Ph.D.
 

Description:

DNA double-strand breaks (DSB) are among the most lethal forms of DNA damage. DSBs are induced by a large number of endogenous and exogenous agents, as genotoxic chemicals and ionizing radiation, or due to replication of damaged DNA as well as collapse of a replication fork. DSB can either be properly repaired, restoring genomic integrity, or miss-repaired resulting in cell death, genomic instability, and cancer. Our group focuses on mechanisms of DSB repair using multi-disciplinary approach (biochemical, structural, computational, genetic, and single-molecule).
 

Laboratory web:  

http://ncbr.chemi.muni.cz/LORD/
 

Research projects:


 

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