Structure and Dynamics of Nucleic Acids
Nucleic acids are compounds of essential importance
for all living organisms. Although the general structural features of regular
DNAs and RNAs are well known, there exist a plethora of structural motifs
different from the regular double helix. Detailed knowledge of the structural
characteristics is necessary for understanding their biological function. NMR
spectroscopy allows studying the structures of nucleic acids oligomers in
solution at close to physiological conditions . The structures of d(C4G4)
d(G4C4) duplexes and
d(GCGAAGC) hairpin were
among those solved in our laboratory.
Schematic representation of the internal dynamics of a tetradecamer RNA hairpin containing GCAA tetraloop. The study was based on 13C NMR relaxation data.