Research group Structural Biology of Gene Regulation


Assoc. Prof. Mgr. Richard Štefl, Ph.D.


The group uses nuclear magnetic resonance (NMR) spectroscopy to study interactions between proteins and RNAs with the aim to gain structural insights into the assembly and function of RNA processing and degradation machineries.

Laboratory web:

Research areas:

  • Protein-RNA and protein-protein interactions and their roles in the regulation of gene expression
  • 3’-end processing and transcription termination
  • NMR spectroscopy of proteins and nucleic acids and their complexes
  • Development and application of new methods to aid the interpretation of NMR data

Main Objectives:

  • Investigation of the role of RNA in gene expression, development and human diseases
  • Establishing an isotope laboratory for NMR studies and the development of new strategies for the preparation of isotopically labelled proteins in eukaryotic cells

Members of the laboratory also participate in research group Structural Biology of Gene Regulation in CEITEC.


Figure: STEFL LAB 2009.


Design © oliver 2007