RESEARCH

Particular projects held at NCBR

Computational and theoretical methods, molecular modeling

• Structure and dynamics of nucleic acids
• Structure and dynamics of proteins and their complexes
• Software development
• Quantum chemistry

Computational studies on nucleic acids

• Structure, dynamics and function of catalytic RNA
• Molecular interactions in nucleic acids

NMR spectroscopy

• Ab initio calculations of NMR parameters
• Novel experimental techniques in nuclear magnetic resonance of biomolecules
• Data and structure validation
• Protein structure and dynamics
• Structure and dynamics of nucleic acids
• Studies of purine derivatives, proton transfer processes, complexations
• Structural studies of isoquinoline alkaloids

Glycobiochemistry and protein engineering of lectins

• Structure-functional studies of prokaryotic and eukaryotic glycosyltransferases
• Structure-functional studies on lectins from pathogenic organisms and their interactions with carbohydrates

Nanobiotechnology

• Development of a novel sensing technique based on nanomechanics for rapid detection of bioagents
• Nanotechnological and bioanalytical detection of the DNA damage

DNA repair and genome stability

• Homologoues recombination and repair of DNA DSB breaks

RNA/Protein interactions

RNA processing and degradation

 

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