Recombination and DNA Repair

Head: doc. Mgr. Lumír Krejčí, Ph.D.

Research Topics

​​DNA double-strand breaks (DSB) are among the most lethal forms of DNA damage. DSBs are induced by many endogenous and exogenous agents, such as genotoxic chemicals and ionizing radiation, or due to the replication of damaged DNA and the collapse of a replication fork.

DSB can either be properly repaired, restoring genomic integrity, or miss-repaired, resulting in cell death, genomic instability, and cancer.

Our group focuses on mechanisms of DSB repair using a multi-disciplinary approach combining biochemical, structural, computational, genetic, and single-molecule approaches.

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