Denys Biriukov, Ph.D.
| E‑mail: |
|
|---|
Research Topics
The research interest of our team lies in exploring the intricate world of glycans (a.k.a. sugars or carbohydrates) and their role in various biological processes. We employ state-of-the-art multiscale molecular simulations to understand their structure, function, and dynamics. Our computer simulations are instrumental in revealing how glycans interact with other biomolecules, impacting crucial processes like cell signaling, immune responses, and disease development. We are dedicated to integrating the latest methodological advancements, developing novel simulation models, and keeping abreast of emerging artificial intelligence applications relevant to our work.
Our current projects center on bacterial glycans and lipopolysaccharides (LPS). By employing molecular dynamics simulations, we examine their behavior and interactions with ions, biomolecules, and polymeric surfaces. We are particularly interested in creating novel functionalization methods for implant coatings to reduce bacterial attachment. This research is pivotal for understanding the role of bacterial glycans and LPS in adhesion and colonization.
The research is conducted in collaboration with multiple experimental groups from the Czech Republic, Europe, and the United States. The research is supported by the Czech Science Foundation.
Main objectives
- Developing novel methods and models for molecular modeling.
- Conducting realistic computer simulations of glycans and their interactions.
- Using computational methods to resolve biological questions.
- Applying acquired knowledge to real-world applications, such as the design of new drugs and materials with targeted functionalities.
- Maintaining a persistent scientific curiosity.