From α-Synuclein Structure to Early Diagnosis of Parkinson’s Disease
Associate Professor Petra Procházková Schrumpfová
National Centre for Biomolecular Research, Faculty of Science
Mendel Centre for Plant Genomics and Proteomics CEITEC
Petra Procházková Schrumpfová has habilitated in the field of Genomics and Proteomics. Her research focuses on plant telomeres. In her habilitation thesis, she focused on the identification, characterization and functional analysis of different types of plant telomere binding proteins, most of which are not strictly telomeric functions, but are also involved in the regulation of gene expression. Her work also provided new information regarding telomere repeat-binding proteins that have similar binding affinities to typical plant and human telomere motifs, which could facilitate adaptation to the alteration of divergent telomere motifs.
Anna Hýsková, Eva Maršálková, and Petr Šimeček compared the accuracy and speed of AlphaFold2, ESMFold, and OmegaFold for protein structure prediction. Their study shows when the superior accuracy of AlphaFold2 justifies its computational cost and when faster alternatives are sufficient.